General Lab News
We say goodbye to two of our lab members: Dr. Kristen Rumer MD,PhD will begin her Colorectal Surgery Clinical Fellowship at Cleveland Clinic Florida and Eileen Tsai, BS will attend The Ohio State University College of Medicine as an MS1.
Congratulations to Dr. Laura Peterson, MD for completing her clinical fellowship in Neonatal-Perinatal Medicine! She has now been appointed as an Instructor at Stanford University School of Medicine, Department of Pediatrics, Division of Neonatology!!!
[June 2020] Eileen Tsai, BS presents Immune Profiling to Predict Recovery Outcomes After Surgery at Shock Society in Toronto, Ontario. [Poster cancelled due to COVID pandemic]
[2 June 2020] Dr. Ina Stelzer, PhD presents “Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset” to the Institute of Computational Biology in Munich. GoToMeeting Link [8am PST]
[13 May 2020] The Gaudilliere lab was awarded seed funding through the Covid Catalyst fund at UC Berkeley’s Center for Emerging and Neglected Diseases for the project “Host response to SARS-CoV-2 infection and predictive modeling of COVID-19 outcomes”. More information here.
[10-14 March 2020] Dr. Ina Stelzer presents Multi-Omic, Longitudinal Profile of Third-trimester Pregnancies Identifies a Molecular Switch That Predicts the Onset of Labor at the Society for Reproductive Investigation (SRI) 67th annual scientific meeting in Vancouver, Canada.
[4 February 2020] Multiomic Immune Clockworks of Pregnancy | Seminars in Immunopathology.| Our latest paper is out!
Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of preterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth. Read it here.
[23-24 January 2020] Dr. Ina Stelzer presented A third trimester multi-omic clock predicts the spontaneous onset of labor at the 3rd German Mass Cytometry User Forum, Berlin, Germany.
[1 Dec. 2019] Congratulations to DR. KAZUO ANDO on his new appointment as a Clinical Instructor in the Department of Anesthesiology, Perioperative and Pain Medicine.
[20 Nov. 2019] Dr. Ina Stelzer gives a talk titled Immune system dynamics in healthy and pathological pregnancies at Fluidigm Bay Area Mass Cytometry Day, UCSF, CA, USA.
[13-16 Nov. 2019] Dr. Ina Stelzer presents Fetal sex influences maternal immune system dynamics over the course of pregnancy at the 14th Congress of the International Society for Immunology of Reproduction (ISIR), Nara, Japan.
CONGRATULATIONS to PROFESSOR XIAOYUAN HAN on her new appointment as an Assistant Professor at University of the Pacific, Arthur A. Dugoni School of Dentistry.
[22-26 June 2019] 34th Congress of the International Society for Advancement of Cytometry, Vancouver, Canada| Come find us at Cyto 2019! Program book.
- Dr. Xiaoyuan Han: Differential Dynamics of the Maternal Immune System in Healthy Pregnancy and Preeclampsia | Sunday 23 June 2019, 11:30 | Ballroom A
- Dr. Laura Peterson: Deep Profiling of the Neonatal Immune System using CyTOF | Tuesday 25 June 2019, 10:50 | Meeting room 1
- Amy Tsai: A Year-Long Immune Profile of the Systemic Response in Acute Stroke Survivors | Wednesday 26 June 2019, 14:45 | Ballroom A
- Dr. Edward Ganio: Deep Immune Profile of Preoperative Glucocorticoid Administration in Patients Undergoing Surgery | Poster B155
- Amy won the 2019 Exceptional Student Award!
[21 June 2019]: Systemic Immunologic Consequences of Chronic Periodontitis | Journal of Dental Research | A high-dimensional analysis of intracellular signaling networks revealed immune system–wide dysfunctions differentiating patients with ChP from healthy controls. Importantly, the immune alterations associated with ChP were no longer detectable 3 wk after periodontal treatment. Our findings demarcate systemic and cell-specific immune dysfunctions in patients with ChP, which can be temporarily reversed by the local treatment of ChP.
[11 June 2019]: Differential Dynamics of the Maternal Immune System in Healthy Pregnancy and Preeclampsia | Frontiers in Immunology | Our paper’s out! Global readout of the dynamics of the maternal immune system early in pregnancy lay the groundwork for identifying clinically-relevant immune dysfunctions for the prediction and prevention of preeclampsia.
- Scope, Stanford Medicine: Predicting women at risk of preeclampsia before clinical symptoms
[9-11 June 2019] Annual Shock Meeting, Coronado, CA | Amy received the Dr. Mohammed Sayeed Presidential Travel Award to present her work at the Annual Shock Meeting. She presents on Sunday, 12:30 pm in Commodore ABCD in the Oral Presentations By and For New Investigators session.
[23 May 2019 ] OKU/Sutro Excellence Day, University of the Pacific, School of Dentistry | The keynote lecture, titled “Profiling the systemic immunological consequences of periodontitis with single cell resolution” was delivered by Dr. Dyani Gaudilliere, clinical assistant professor of Surgery (Plastic Surgery), and chief of Dental Medicine & Surgery, and Dr. Brice Gaudillaire, assistant professor of Anesthesiology, both from Stanford School of Medicine.
[16-20 May 2019] AUA/IARS/SOCCA, Montréal, Canada | Kosaka Award Finalist | Our work on the deep immune profile of preoperative glucocorticoid administration in patients undergoing surgery was a finalist for the Kosaka awards.
[12 March 2019]: A year-long immune profile of the systemic response in acute stroke survivors | Brain | Our paper on early differences in immunological responses to stroke that are associated with functional outcomes one year from stroke onset is published and available!
- Science News: Stroke victims with busy immune responses may also see mental declines
- Scope, Stanford Medicine| Needle in a haystack: Two days after stroke, a handful of blood cells reveal risk of dementia a year later
[12-16 March 2019] 66th Annual Scientific Meeting, Society for Reproductive Investigations, Paris, France | Program Book | Dr. Xiaoyuan Han presents Differential Dynamics of the Maternal Immune System in Healthy Pregnancy and Preeclampsia (Poster F-186).
[4 March 2019] MCHRI Seminar Series | Drs Brice Gaudilliere and Laura Peterson discuss the immune system dynamics in normal and pathological pregnancies and deep immune profiling of the neonatal immune system.
[Feb 2019] Dr. Ina Stelzer recieves Forschungsstipendium from the Deutsche Forschungsgemeinschaft.
[Jan 2019] Western Society of Pediatric Research, Carmel, California | Dr. Laura Peterson presents her work on neonatal outcomes.
and maternal health.
[ December 2015]
[9/24/14] Gaudilliere et. al
Multiomic immune clockworks of pregnancy. Seminars in immunopathology. 2020
Systemic immunological consequences of chronic periodontitis. Journal of Dental Research. Gaudilliere DK, Culos A, Djebali K, Tsai AS, Ganio EA, Chio WM, Maghaireh A, Choisy B, Ando K, Baca Q, Bertrand B, Einhaus JF, Hedou JJ, Fallahzadeh R, Ghaemi MS, Han X, Okada R, Stanley N, Tanada A, Tingle M, Alpagot T, Helms JA, Angst MS, Aghaeepour N, Gaudilliere B. 2019.
Differential dynamics of the maternal immune system in healthy pregnancy and preeclampsia. Frontiers in Immunology. 2019; 10
How Clinical Flow Cytometry Rebooted Sepsis Immunology CYTOMETRY PART A. 2019; 95A (4): 431–41
Predicting Acute Pain After Surgery: A Multivariate Analysis. Annals of surgery. 2019
Multiomics Modeling of the Immunome, Transcriptome, Microbiome, Proteome, and Metabolome Adaptations During Human Pregnancy. Bioinformatics. MS Ghaemi, DB DiGiulio, K Contrepois, B Callahan, TTM Ngo, BA Lee, B Lehallier, D Mcilwain, Y Rosenberg-Hasson, RJ Wong, C Quaintance, A Culos, A Tanada, A Tsai, D Gaudilliere, E Ganio, X Han, K Ando, L McNeil, R Okada, M Tingle, P Wise, I Maric, M Sirota, T Wyss-Coray, VD Winn, ML Druzin, R Gibbs, GL Darmstadt, DB Lewis, VP Nia, B Agard, H Maecker, R Tibshirani, G Nolan, MP Snyder, DA Relman, SR Quake, GM Shaw, DK Stevenson, MS Angst, B Gaudilliere, N Aghaeepour. 2018.
Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery. Journal of Immunology. Aghaeepour, N., Kin, C., Ganio, E. A., Jensen, K. P., Gaudilliere, D. K., Tingle, M., Tsai, A., Lancero, H. L., Choisy, B., McNeil, L. S., Okada, R., Shelton, A. A., Nolan, G. P., Angst, M. S., Gaudilliere, B. L. 2017.
Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go! Critical care medicine. 2017; 45 (9): 1577–78.
Mass cytometry: The time to settle down. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2017; 91 (1): 12–13
Freehand Versus Guided Surgery: Factors Influencing Accuracy of Dental Implant Placement. Implant dentistry. 2017; 26 (4): 500–509
The road ahead: Implementing mass cytometry in clinical studies, one cell at a time. Cytometry. Part B, Clinical cytometry
A Proteomic Clock of Human Pregnancy. American journal of obstetrics and gynecology. 2017
Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. Journal of immunology. 2016
Patient-specific Immune States before Surgery Are Strong Correlates of Surgical Recovery. ANESTHESIOLOGY. 2015; 123 (6): 1241-1255
Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2015; 87 (9): 817-829
Clinical recovery from surgery correlates with single-cell immune signatures. Science Translational. Gaudillière B, Fragiadakis GK, Bruggner RV, Nicolau M, Finck R, Tingle M, Silva J, Ganio EA, Yeh CG, Maloney WJ, Huddleston JI, Goodman SB, Davis MM, Bendall SC, Fantl WJ, Angst MS, Nolan GP. 2014; Vol. 6, Issue 255, pp. 255ra131. DOI: 10.1126/scitranslmed.3009701